Injectable SF Hydrogel (iSFH)

Injectable SF Hydrogel (iSFH) developed

Diabetes affects more than 70 million people in India, the second-highest in the world. It results from inadequate production of insulin due to loss of beta cells or insulin resistance within the body.

Injectable SF Hydrogel (iSFH) developed

GS Paper III: Science and Technology – developments and their applications and effects in everyday life Achievements of Indians in science & technology; indigenization of technology and developing new technology.

Context: Scientists at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) have recently developed an injectable Silk fibroin-based hydrogel for sustained insulin delivery in diabetic patients.

  • Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) is an autonomous research institute under the Department of Science and Technology, Governement of India.
  • The current research was funded by JNCASR, Bengaluru, BRICS Multilateral R&D Projects grant, and Department of Science and Technology (DST), Govt. of India under Swarna Jayanti Fellowship Grant and DST-Nano mission.
Injectable SF Hydrogel (iSFH)


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What you should know about Injectable SF Hydrogel (iSFH)?

  • The silk fibroin (SF) formulation has been developed using biocompatible additives.
  • The prepared injectable SF hydrogel (iSFH) can ease insulin delivery in diabetic patients.
  • The iSFH has demonstrated successful delivery of active insulin in rats.
  • The scientists have shown that subcutaneous (supplied under the skin) injection of insulin with-iSFH in diabetic rats formed active depot under the skin from which insulin trickled out slowly and restored the physiological glucose homeostasis for a prolonged period of 4 days with no risks of low blood sugar through sudden burst of high concentration of insulin into the blood.
  • The iSFH has proved to be an effective insulin delivery tool for diabetic patients with excellent mechanical strength, biocompatibility, encapsulation, storage, and demonstration of its sustained delivery of active insulin in the diabetic animal.

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What is the need of iSFH?

Diabetes affects more than 70 million people in India, the second-highest in the world. It results from inadequate production of insulin due to loss of beta cells or insulin resistance within the body, which imbalances the glucose homeostasis is leading to an abrupt increase of blood glucose level.

  • The conventional and last resort of treatment involves repeated subcutaneous insulin injections to maintain the physiological glucose homeostasis.
  • The multiple subcutaneous insulin injections are associated with pain, local tissue necrosis, infection, nerve damage, and locally concentrated insulin amyloidosis responsible for inability to achieve physiological glucose homeostasis.
  • This problem can be overcome with controlled and sustained insulin delivery.
  • Thus, encapsulation and sustained delivery of insulin in its active form (without loss of activity) is the key to the development of such controlled and sustained in vivo delivery of Insulin.
  • The active encapsulation and delivery of insulin by iSFH may also have implications for the future development of formulations for oral insulin delivery.

SOURCE | Press Information Bureau



PRELIMS Background Bites


About Swarnajayanti Fellowship Scheme

  • Govt. of India had instituted a scheme “The Swarnajayanti Fellowships” to commemorate India’s 50th year of Independence.
  • Under this scheme, a selected number of young scientists, with proven track record, are provided special assistance and support to enable them to pursue basic research in frontier areas of science and technology.
  • The fellowships are scientist specific and not institution specific, very selective and have close academic monitoring.
  • The award consists of a Fellowship of Rs 25000/- per month in addition to the salary drawn from the parent Institute along with a Research Grant of Rs 5 lakh per annum by Department of Science and Technology for a period of 5 years.
  • The project submitted by the selected Fellows will be considered for funding by the Science & Engineering Research Board (SERB) as per SERB norms, for recurring and non-recurring heads.
  • The duration of the fellowship will be for a period not exceeding five years.

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